Clinical/Practical Syllabus, Notes & PYQ for GGSIPU Doctor of Medicine Overview
Doctor of Medicine
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Clinical/Practical
1Analgesic
2Anti-inflammatory
3Antipyretic; pyrogen testing
4Anticonvulsant
5Antianxiety
6Antipsychotic
7Antidepressant
8Antiparkinsonian
9Sedative, hypnotics
10Antihypertensive
11Antianginal
12Antiarrhythmic
13Skeletal muscle relaxant
14Antiasthmatic
15Local anaesthetic
16Antihistaminics, antiallergic
17Drugs for peptic ulcer
18Antiemetic
19Hypoglycaemic
20Antifertility
21Anticancer
22Diuretic
23Antimalarial
24Antitubercular
25Antidiabetic
26Antiatherosclerotic
27Bronchodilator drugs
28Bioassay of: Acetylcholine
29Bioassay of: Adrenaline/noradrenaline
30Bioassay of: Histamine
31Bioassay of: 5-hydroxytryptamine
32Methods for studying absorption, biotransformation and excretion of drugs.
33Limitations of animal experiments in drug evaluation.
34Quantitative study of agonists and antagonists on isolated tissues.
35Measurement of blood pressure in conscious and anaesthetized animals.
36Extraction, purification and characterization of active principles from plant sources/crude products.
37Frog’s rectus abdominis muscle: dose response curve (DRC) and cumulative DRC of acetylcholine; potentiation of Ach by physostigmine and antagonism by tubocurarine/pancuronium.
38Study of drug action on perfused frog’s heart.
39Study of drug action on isolated rabbit ileum.
40Dose-response curve of histamine on isolated guinea pig ileum, cumulative dose response curve of histamine in isolated guinea pig tracheal chain.
41Bioassay of histamine on guinea pig ileum by matching method, 3 point method and 4 point (Latin square design) method.
42Bioassay of Ach on frog’s rectus abdominis muscle.
43Determination of EC50 and pA2 values of histamine and Ach on guinea pig ileum and frog rectus abdominis muscles.
44Determination of ED50 and pA2 values of chlorpheniramine, pancuronium.
45Bio-assay of adrenaline on rabbit duodenum.
46Bio-assay of adrenaline on rat B.P.
47Bio-assay of 5-HT on estrogen primed rat uterus.
48Demonstration of muscarinic and nicotinic actions of Ach and carbachol on the B.P. and respiration of anaesthetized dog/cat.
49Demonstration of cholinesterase activity in blood and anti-cholinesterase activity of physostigmine using B.P. and respiration of anaesthetized dog/cat.
50Demonstration of tachyphylaxis with ephedrine and vasomotor reversal phenomenon on B.P. and respiration of anaesthetized dog/cat.
51Identification of the nature of unknown drug using B.P. and nictitating membrane contractions of anaesthetized cat.
52Identification of the nature of unknown drug using B.P. and spleen volume of anaesthetized dog.
53Identification of the nature of unknown drug using B.P. and intestine in situ of anaesthetized dog.
54Study of drug action on isolated perfused rabbit heart (Langendorff’s technique).
55Study of drug action on isolated rabbit auricles.
56Demonstration of rabbit head drop with d-tubocurarine and its reversal by neostigmine.
57Study of neuromuscular blocking agents using Phrenic nerve-diaphragm preparation of rat.
58Study of local anaesthetics by rabbit cornea, guinea pig intradermal wheal, frog lumbar plexus.
59Study of anticonvulsant activity of drugs on maximal electroshock seizures and drug induced convulsions in rats.
60Study of analgesic activity of drugs using rat tail-hot wire methods, hot plate method, and acetic acid induced writhing.
61Study of anti-inflammatory activity of drugs against carrageenin induced rat paw oedema.
62Antagonism of histamine aerosol induced bronchospasm by anti-histaminics.
63Effect of psychopharmacological drugs on conditioned avoidance response (Cook’s pole climbing).
64Effect of psychopharmacological agents on foot shock induced aggression in rats.
65Effect of psychopharmacological agents on elevated plus maze.
66Effect of drugs on spontaneous motor activity of mice, photoactometer.
67Study of anorectic activity of amphetamine in mice.
68Potentiation of barbiturate hypnosis by chlorpromazine.
69Study of miotics and mydriatics on rabbit’s eye.
70Mouse tail vein injection.
71Administration of drugs to rats by gastric cannula.
72Collection of blood from rat tail.
73Collection of blood by cardiac puncture in rat.
74Injection of drugs through marginal ear vein of rabbits.
75Intraperitoneal and subcutaneous injection to rats and mice.
76Intracerebroventricular injection in rat.
77Estimation of drug levels using colorimetry, spectrophotometry, fluorimetry, flame photometry, high performance liquid chromatography (HPLC), enzyme linked immunoassay.
78Recording B.P. in human volunteers.
79Recording of ECG and measurement of heart rate, PR interval, QT interval, ST segment depression etc. in human volunteers.
80Study of effect of sublingual nitroglycerine tablet on B.P. and heart rate.
81Study of effect of Beta-blockers on exercise tolerance in volunteers.
82Spirometry and respiratory function tests and effect of bronchodilators.
83Psychomotor testing in volunteers.
84Assessment of analgesic activity in volunteers.
85Mydriatic, miotic and cycloplegic effect of drugs in human subjects.
86Effect of anticholinergic drugs on salivation, pupillary size, heart rate and memory.
87Molarity calculations and preparations of reagents.
88Estimation of serum salicylate levels using spectrofluorimetric method.
89Estimation of plasma phenobarbitone concentration using spectrophotometer.